Two modern-day people – a man (a civil servant in an administrative post) and a woman (a PhD Candidate in History) – , strangers, run into each other in the carriage of an electric train during a late night route. After an unexpected power cut, an ordinary small talk gives way to a game; to overcome the awkward moment, they decide to play a role-playing children’s game. Each of them will impersonate a specific historical or fictional character; the man will portray "Joseph Mengele", the infamous "Angel of Death" of Auschwitz, while the woman will portray "Esther", the granddaughter of a Jew survivor and who fell victim to the horrible experiments of the mysterious doctor. Soon, however, the game takes a different turn for the two people who are trapped in the train: could it be that they actually are the characters they impersonate? How far can they take this "game" when issues regarding moral values, the human condition and History emerge?

Mengele is an edgy play, oscillating between classic extremity and modern jeopardy. An extreme moral parable, a post-political dystopia, a science-fiction thriller and a heartbreaking romantic tragedy intertwine beyond the boundaries of morality, in the invisible threshold where the fiercest of loves meet ultimate evil.